After 12 years of research, the Alzheimer’s Disease Neuroimaging Initiative (ADNI) will begin the third phase in their Alzheimer’s research study. The study (ADNI3) led by the National Institute on Aging will be funded over the next five years with $40 million from the National Institutes of Health and an additional $20 million from the Foundation for the National Institutes of Health. Approximately 2,000 people over the age of 55 from all over the US and Canada will be studied, 1200 of which were recruited in September 2016. The volunteers represent the full range of the Alzheimer’s disease from normal cognition to Alzheimer’s dementia.
The focus of this study is to provide scientists with a better understanding of how the brain and chemicals in body fluids are affected by the Alzheimer’s disease. Scientists will compare changes in cognitive tests to changes in biological markers, also referred to as Biomarkers, found in body fluids such as blood, cerebrospinal fluid, and DNA. Scientists will be investigating biomarkers, which indicate the onset and progression of the disease, and use samples from volunteers to study chemical changes and further understand the role genes play in Alzheimer’s. ADNI3 will use innovative, state-of-the-art brain scanning technology to study the earliest changes in the brain’s structure and function, as well as monitor levels of the tau protein, which is abnormal in patients with Alzheimer’s.
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